Measles – Rubella(MR) and Measles – Mumps – Rubella (MMR) combination


What are the MR and MMR vaccination?

• In the United States, the vaccine was licensed in 1963 and the second dose was introduced in the mid 1990s. It is widely used around the world; since introduction of its earliest versions in the 1970s, over 500 million doses have been used in over 60 countries.

• MMR vaccine administered against measles, mumps (epidemic parotitis is a viral disease) and rubella (German measles).


• Some countries use combination vaccinations for measles and rubella (MR) or for measles, mumps and rubella (MMR) vaccines are provide in powder form with diluents and must be reconstituted before they can be used. It is essential that only the diluents supplied with the vaccine be used.

• MR and MMR vaccines should be kept at 2C -8C after reconstitution vaccine must be discarded after six hours or at the end of immunization session, whichever comes first.


How safe the MR and MMR vaccines and what are their potential side-effect?

Mild reactions to the vaccines include:

– Fever: as with the single – antigen measles vaccine, about 5% to 10% of children develop a mild fever within 5 to 12 days of receiving the vaccine.

– Rash: again as with the measles vaccine, about one in 20 children develop a mild rash about 5 to 12 days after being immunized.

Sever reaction:

– are rare and similar to that experienced after receipt of the measles vaccine. although an association between MMR and autism has been.

– suggested. There absolute no evidence of a link between the MMR vaccine and autism accorded to study in 2004, UK.

– in addition rubella containing vaccines may result in temporary from arthritis from one to three weeks after vaccination in up to one in four post pubertal females. These reactions are very rare in young children.

-  Mumps – containing vaccines may result in rare cases of parotitis and some cases of septic meningitis. Children recover without squeals although some may need to be hospitalized


– The risk of developing this complication varies depending on vaccine strain used.


Administration Summary of MMR vaccine

Type of vaccine

Live attenuated viral

Number of doses

One dose.


Generally 12 -15 months.

In 15 month


A second opportunity for measles immunization is recommended (routine or campaign)


Sever reaction to pervious dose: pregnancy; congenital or acquired immune disorders (not HIV infection). although not recommended to administer the vaccine during pregnancy, there has never been any evidence of damage to the fetus from vaccination the mother during pregnancy.

Adverse reaction

Same as measles vaccine, plus cases of arthritis in adolescent females for rubella- containing vaccine and parotitis; rarely aseptic meningitis with mumps – containing vaccine may occur.

Special precaution




Injection site

Outer mid-thigh in infant / outer upper arm if older

Injection type



Store between 2C- (vaccine may be frozen for long – term storage but not the diluents)

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