Hepatitis B (Hep. B) Vaccine


What is hepatitis B Vaccine?

• Hepatitis B vaccine is a cloudy liquid that is provided single or multi- dose vials or in profiled auto – disable (AD) injection devices. Because the hep B vaccine contains only one antigen, it is called monvalent hep B vaccine is also available in combination DTP – HepB and DTP – HepB +Hib vaccines.

• Only monovalent hep B vaccine should be used as a birth dose, the dose given within the first week of life.

• Combination vaccines should not be used at birth, but may be used in subsequent doses. May separate from the liquid. If hep B vaccine stands for a long time, the vaccine may separate from the liquid. When separated, the vaccine looks like fine sad at the bottom of the vial. Shake the vial to mix the vaccine and liquid before using the vaccine hep B should never be frozen. The "shake test" "see figure 3" will determine if the vaccine has been damaged by freezing. If the vaccine fails the shake test, you must discard it.


Shaking Test



How safe is HepB vaccine, what are their potential side- effects?


– Hep B vaccine is one of the safest vaccines

Mild reaction includes:

• Soreness: about 15% of adults and 5% of children have tenderness or mild swelling at the injection site.

• Fever: about 1% to 6% of those who receive the vaccine develop a mild fever that lasts one or two days after injection of the vaccine. 


• Reaction and complication due to the vaccine are rare; allergic reactions; such as rash, difficulty in breathing, and choking, occur about once every 600,000 doses. No fatal allergic reaction has been reported


Administration summary of Hepatitis B vaccine

Type of vaccine

Recombinant DNA or plasma derived

Number of doses

Three doses


Several option

In 0.1.6 month of age

Booster None


Anaphylactic reaction to a previous dose

Adverse reactions

Local soreness and redness, rarely anaphylactic reaction.

Special precautions

Birth dose must be given if there is a risk of perinatal transmission



Injection site

Outer mid thigh (infants) outer upper arm (child and adult)

Injection type


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