Cerebral Perfusion Pressure (CPP)

Cerebral Perfusion Pressure

Cerebral Perfusion Pressure (CPP)
–    Pressure needed to maintain blood flow to the brain: Normal CPP is 60-100 mmHg
–    CPP>100 is hyperperfusion and IICP
–    CPP< 60 hypoperfusion
–    CPP<30 incompatible with life (ischemia, death)

Note:
–    Brain uses 25% of body’s glucose
–    Brain uses 20% of the body’s oxygen

Metabolic Factors affecting cerebral blood flow
–    Oxygen tension – When oxygen tension (PaO2) falls below 50, cerebral arteries dilate to increase cerebral blood flow.
–    Carbon dioxide tension – If the blood becomes acidic, the blood vessels dilate to increase cerebral blood flow (increased CO2 and acidosis are potent vasodilators)
–    Globally: Extreme cardiovascular changes (asystole) or Pathophysiologic states (diabetic coma)
–    Focally: Trauma and tumors

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